麻豆国产成人AV在线_午夜国产精品视频在线_99视频精品国产免费观看_美女禁止的网站免费_嘿嘿视频官方在线页面入口页面弹窗免费下载_日本高清专区一区二无线_幸福宝下载深夜释放自己_美女写真福利视频网站

加入收藏 | 設(shè)為首頁(yè) | 聯(lián)系我們

產(chǎn)品搜索

產(chǎn)品分類

聯(lián)系我們

聯(lián)系人：蔣經(jīng)理
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com

產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73186EML4-ALK V3b/BaF3

EML4-ALK V3b/BaF3
名稱 EML4-ALK V3b/BaF3
型號(hào) CBP73186
報(bào)價(jià)
特點(diǎn) EML4-ALK V3b/BaF3,母細(xì)胞：BaF3，凍存條件：90% FBS+10% DMSO
  • 詳細(xì)內(nèi)容


CBP73186
I. Introduction

Cell Line Name：

EML4-ALK V3b/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10% FBS+2ug/ml puromycin

Mycoplasma Status:

Negative


II.Background

Approximately 3–7% of lung tumors harbor ALK fusions (Koivunen et al. 2008; Kwak et al. 2010; Shinmura et al. 2008; Soda et al. 2007; Takeuchi et al. 2008; Wong et al. 2009). ALK fusions are more commonly found in light smokers (< 10 pack years) and/or never-smokers (Inamura et al. 2009; Koivunen et al. 2008; Kwak et al. 2010; Soda et al. 2007; Wong et al. 2009). ALK fusions are also associated with younger age (Inamura et al. 2009; Kwak et al. 2010; Wong et al. 2009) and adenocarcinomas with acinar histology (Inamura et al. 2009; Wong et al. 2009) or signet-ring cells (Kwak et al. 2010). Clinically, the presence of EML4-ALK fusions is associated with EGFR tyrosine kinase inhibitor (TKI) resistance (Shaw et al. 2009).

Multiple different ALK rearrangements have been described in NSCLC. The majority of these ALK fusion variants are comprised of portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene with the ALK gene. At least nine different EML4-ALK fusion variants have been identified in NSCLC (Figure 1; Choi et al. 2008; Horn and Pao 2009; Koivunen et al. 2008; Soda et al. 2007; Takeuchi et al. 2008; Takeuchi et al. 2009; Wong et al. 2009). In addition, non-EML4 fusion partners have also been identified, including KIF5B-ALK (Takeuchi et al. 2009) and TFG-ALK (Rikova et al. 2007). Clinically, the presence of an ALK rearrangement is detected by fluorescence in situ hybridization (FISH) with an ALK break apart probe. FISH testing is not able to discern which particular ALK fusion is found in a clinical sample.


III. Representative Data

1. WB of EML4-ALK V3b/BaF3 expression

CBP73186 WB.jpg

Figure 1. WB of ALK expression

2. Anti-proliferation assay


Figure 2. Anti-proliferation assay of three reference compounds on the EML4-ALK V3b/BaF3 Stable Cell Line




如果你對(duì)CBP73186EML4-ALK V3b/BaF3感興趣，想了解更詳細(xì)的產(chǎn)品信息，填寫(xiě)下表直接與廠家聯(lián)系：


留言框

  • 產(chǎn)品：

  • 您的單位：

  • 您的姓名：

  • 聯(lián)系電話：

  • 常用郵箱：

  • 省份：

  • 詳細(xì)地址：

  • 補(bǔ)充說(shuō)明：

  • 驗(yàn)證碼：

    請(qǐng)輸入計(jì)算結(jié)果（填寫(xiě)阿拉伯?dāng)?shù)字），如：三加四=7

化工儀器網(wǎng)

推薦收藏該企業(yè)網(wǎng)站
精品黑人一区二区三区| 国产一级精品视频| 曰本无码人妻丰满熟妇啪啪| 亚洲xx网| 精品一区二区三区中文字幕视频| 国产激情综合| 黄色无码大片| 四川熟女大白屁股91爽| 日韩无码性爱视频| 嫩草在线视频| 亚洲激情视频| 亚洲成a人片7777777影片| 国产精品主播| 91人妻人人澡人人爽人人精吕| 国产成人三级片| 日韩三级一区二区| 全黄一级毛片免费| 亚洲视频www| 性爱欧美第二区| 国产操逼视频免费看|